ORIGINAL ARTICLE
Year : 2018 | Volume
: 6 | Issue : 1 | Page : 17--21
Study of biochemical profile and 25-hydroxy Vitamin D association with disease activity in rheumatoid arthritis patients
Regupathy Annamalai1, Amar Nagesh Kumar2 1 Department of Orthopedics, Karpaga Vinayaga Institute of Medical Sciences and Research Center, Kancheepuram, Tamil Nadu, India 2 Department of Biochemistry, Karpaga Vinayaga Institute of Medical Sciences and Research Center, Kancheepuram, Tamil Nadu, India
Correspondence Address:
Dr. Regupathy Annamalai Department of Orthopedics, Karpaga Vinayaga Institute of Medical Sciences and Research Center, Madhurantagam, Kancheepuram, Tamil Nadu India
BACKGROUND: Vitamin D deficiency has been implicated in the pathogenesis of autoimmune diseases. Reduced Vitamin D intake has been linked to increased susceptibility to the development of rheumatoid arthritis�(RA). The objective was to evaluate 25-hydroxy�(25-OH) Vitamin D status in patients with RA and to assess the relationship between Vitamin D level and RA disease activity.
MATERIALS AND METHODS: The study consists of 50 RA patients as cases and 50 age-�and body mass index matched healthy individuals as controls. All study participants�(both controls and cases) underwent biochemical profile such as RA factor, serum uric acid�(UA), calcium, phosphorous, alkaline phosphatase, and 25-OH Vitamin D levels. Disease activity was evaluated by calculating the 28-joint count as disease activity score. All the results were expressed as mean and standard deviation�(SD).
RESULTS: Mean and SD values of serum UA�(mg/dl), calcium�(mg/dl), and phosphorous levels (mg/dl) in RA cases are as follows 7.2�±�1.3, 7.5�±�0.5, and 6.9�±�1.5, respectively. Serum UA, calcium, and phosphorous levels in RA cases were found to be elevated when compared to controls�(P�<�0.0001). Mean erythrocyte sedimentation rate was 58.4�±�14.7�mm/h in the group of patients with RA. Levels of 25-OH Vitamin D were found to be negatively correlated to the DAS28, the correlation coefficient being r = −0.51�(P�<�0.05). Levels of 25-OH Vitamin D were found to be positively correlated to serum calcium levels, the correlation coefficient being r�=�0.82�(P�<�0.01).
CONCLUSION: RA patients had lower Vitamin D values than healthy controls. There was a negative correlation between serum Vitamin D and RA disease activity.
How to cite this article:
Annamalai R, Kumar AN. Study of biochemical profile and 25-hydroxy Vitamin D association with disease activity in rheumatoid arthritis patients.J Orthop Allied Sci 2018;6:17-21
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How to cite this URL:
Annamalai R, Kumar AN. Study of biochemical profile and 25-hydroxy Vitamin D association with disease activity in rheumatoid arthritis patients. J Orthop Allied Sci [serial online] 2018 [cited 2024 Mar 29 ];6:17-21
Available from: https://www.joas.in/article.asp?issn=2319-2585;year=2018;volume=6;issue=1;spage=17;epage=21;aulast=Annamalai;type=0 |
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