Journal of Orthopaedics and Allied Sciences

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 6  |  Issue : 1  |  Page : 17--21

Study of biochemical profile and 25-hydroxy Vitamin D association with disease activity in rheumatoid arthritis patients


Regupathy Annamalai1, Amar Nagesh Kumar2 
1 Department of Orthopedics, Karpaga Vinayaga Institute of Medical Sciences and Research Center, Kancheepuram, Tamil Nadu, India
2 Department of Biochemistry, Karpaga Vinayaga Institute of Medical Sciences and Research Center, Kancheepuram, Tamil Nadu, India

Correspondence Address:
Dr. Regupathy Annamalai
Department of Orthopedics, Karpaga Vinayaga Institute of Medical Sciences and Research Center, Madhurantagam, Kancheepuram, Tamil Nadu
India

BACKGROUND: Vitamin D deficiency has been implicated in the pathogenesis of autoimmune diseases. Reduced Vitamin D intake has been linked to increased susceptibility to the development of rheumatoid arthritis�(RA). The objective was to evaluate 25-hydroxy�(25-OH) Vitamin D status in patients with RA and to assess the relationship between Vitamin D level and RA disease activity. MATERIALS AND METHODS: The study consists of 50 RA patients as cases and 50 age-�and body mass index matched healthy individuals as controls. All study participants�(both controls and cases) underwent biochemical profile such as RA factor, serum uric acid�(UA), calcium, phosphorous, alkaline phosphatase, and 25-OH Vitamin D levels. Disease activity was evaluated by calculating the 28-joint count as disease activity score. All the results were expressed as mean and standard deviation�(SD). RESULTS: Mean and SD values of serum UA�(mg/dl), calcium�(mg/dl), and phosphorous levels (mg/dl) in RA cases are as follows 7.2�±�1.3, 7.5�±�0.5, and 6.9�±�1.5, respectively. Serum UA, calcium, and phosphorous levels in RA cases were found to be elevated when compared to controls�(P�<�0.0001). Mean erythrocyte sedimentation rate was 58.4�±�14.7�mm/h in the group of patients with RA. Levels of 25-OH Vitamin D were found to be negatively correlated to the DAS28, the correlation coefficient being r = −0.51�(P�<�0.05). Levels of 25-OH Vitamin D were found to be positively correlated to serum calcium levels, the correlation coefficient being r�=�0.82�(P�<�0.01). CONCLUSION: RA patients had lower Vitamin D values than healthy controls. There was a negative correlation between serum Vitamin D and RA disease activity.


How to cite this article:
Annamalai R, Kumar AN. Study of biochemical profile and 25-hydroxy Vitamin D association with disease activity in rheumatoid arthritis patients.J Orthop Allied Sci 2018;6:17-21


How to cite this URL:
Annamalai R, Kumar AN. Study of biochemical profile and 25-hydroxy Vitamin D association with disease activity in rheumatoid arthritis patients. J Orthop Allied Sci [serial online] 2018 [cited 2024 Mar 29 ];6:17-21
Available from: https://www.joas.in/article.asp?issn=2319-2585;year=2018;volume=6;issue=1;spage=17;epage=21;aulast=Annamalai;type=0