Table of Contents  
Year : 2015  |  Volume : 3  |  Issue : 2  |  Page : 53-54

Effects of platelet-rich plasma in supraspinatus tendinopathy

Department of Orthopaedics, Datta Meghe Institute of Medical Sciences, Wardha, Maharashtra, India

Date of Web Publication23-Oct-2015

Correspondence Address:
Pradeep K Singh
Department of Orthopaedics, Datta Meghe Institute of Medical Sciences, Wardha - 442 001, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2319-2585.167981

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How to cite this article:
Singh PK, Saxena NK, Khan S. Effects of platelet-rich plasma in supraspinatus tendinopathy. J Orthop Allied Sci 2015;3:53-4

How to cite this URL:
Singh PK, Saxena NK, Khan S. Effects of platelet-rich plasma in supraspinatus tendinopathy. J Orthop Allied Sci [serial online] 2015 [cited 2023 Oct 3];3:53-4. Available from:

Supraspinus tendinopathy is a common and perplexing problem in current clinical practice. It is one of the most common reason that patients seek medical attention accounts for patient visits to a medical practitioner.[1] The most common reason for the supraspinatus tendinopathy is overuse injuries in sports as well as in jobs that require repetitive activity.[2],[3],[4],[5] Shoulder impingement is one of the most common causes of shoulder tendinopathy [6],[7],[8] and refers to the compression of the subacromial structures against the coracoacromial ligament during the elevation of the arm.[9] Excessive mechanical loading is considered the major causation factor. However, tendon problems are very frequent, and no clinical guidelines available to manage such problems. Apoptosis,[10] vascular changes [11],[12] tears [13] and calcifications [14] of the supraspinatus tendon have been described in subjects who were treated with subacromial decompression.

Although originally considered an inflammatory problem, histopathologic analysis of tendinopathy has revealed evidence that this process is predominantly degenerative and is characterized by hypercellularity, vascular hyperplasia, and collagen disorganization. Since tendinopathy is primarily a degenerative condition, several new treatments have been developed in an attempt to stimulate tissue regeneration. One of these treatments is an injection of platelet-rich plasma (PRP). The use of autologous growth factors in the form of PRP may be just the beginning of a new medical frontier known as “orthobiologics.” PRP is a new technology focused on enhancing the healing response after injury of different tissue types.[15],[16]

In tendinopathy, changes in the composition of the tendinous matrix are in part mediated by inflammatory mediators and metalloproteinase enzymes and are consistent with changes in cell-mediated matrix remodeling, which precedes the onset of clinical symptoms. These biochemical changes around tendon may represent patients whom PRP may be beneficial. However, corticosteroids could mediate their own effect thorough alterations in the release of these harmful chemicals agents, the behavior of their receptors, or both.[17] Essentially, corticosteroid aims to achieve a reduction in inflammation, but a negative effect on neo-vascularization by a general inhibition of protein synthesis.[18] However, the patient who receives PRP may respond better due to the fact that human tenocytes with degenerative lesions showed neo-vascularization and new tenocytes formation.[19],[20]

It can also be hypothesized that the PRP can be a good treatment option for the patients with supraspinatous tendinopathy who had involvement of substance of tendon and needed regeneration of the tendon.

  References Top

Järvinen M. Epidemiology of tendon injuries in sports. Clin Sports Med 1992;11:493-504.  Back to cited text no. 1
Camargo PR, Haik MN, Ludewig PM, Filho RB, Mattiello-Rosa SM, Salvini TF. Effects of strengthening and stretching exercises applied during working hours on pain and physical impairment in workers with subacromial impingement syndrome. Physiother Theory Pract 2009;25:463-75.  Back to cited text no. 2
Cools AM, Declercq G, Cagnie B, Cambier D, Witvrouw E. Internal impingement in the tennis player: Rehabilitation guidelines. Br J Sports Med 2008;42:165-71.  Back to cited text no. 3
Martins LV, Marziale MH. Assessment of proprioceptive exercises in the treatment of rotator cuff disorders in nursing professionals: A randomized controlled clinical trial. Rev Bras Fisioter 2012;16:502-9.  Back to cited text no. 4
Marcondes FB, de Jesus JF, Bryk FF, de Vasconcelos RA, Fukuda TY. Posterior shoulder tightness and rotator cuff strength assessments in painful shoulders of amateur tennis players. Braz J Phys Ther 2013;17:185-94.  Back to cited text no. 5
Burke WS, Vangsness CT, Powers CM. Strengthening the supraspinatus: A clinical and biomechanical review. Clin Orthop Relat Res 2002;402:292-8.  Back to cited text no. 6
Littlewood C. Contractile dysfunction of the shoulder (rotator cuff tendinopathy): An overview. J Man Manip Ther 2012;20:209-13.  Back to cited text no. 7
Lewis JS. Rotator cuff tendinopathy/subacromial impingement syndrome: Is it time for a new method of assessment? Br J Sports Med 2009;43:259-64.  Back to cited text no. 8
Neer CS 2nd. Anterior acromioplasty for the chronic impingement syndrome in the shoulder: A preliminary report. J Bone Joint Surg Am 1972;54:41-50.  Back to cited text no. 9
Tuoheti Y, Itoi E, Pradhan RL, Wakabayashi I, Takahashi S, Minagawa H, et al. Apoptosis in the supraspinatus tendon with stage II subacromial impingement. J Shoulder Elbow Surg 2005;14:535-41.  Back to cited text no. 10
Carr A, Harvie P. Rotator cuff tendinopathy. In: Maffulli N, Renström P, Leadbetter WB, editors. Tendon Injuries: Basic Science and Clinical Medicine. London: Springer; 2005. p. 101-18.  Back to cited text no. 11
Biberthaler P, Wiedemann E, Nerlich A, Kettler M, Mussack T, Deckelmann S, et al. Microcirculation associated with degenerative rotator cuff lesions.In vivo assessment with orthogonal polarization spectral imaging during arthroscopy of the shoulder. J Bone Joint Surg Am 2003;85-A:475-80.  Back to cited text no. 12
Bunker T. Rotator cuff disease. Curr Orthop 2002;16:223-33.  Back to cited text no. 13
Hughes PJ, Bolton-Maggs B. Calcifying tendonitis. Curr Orthop2002;16:389-94.  Back to cited text no. 14
Kraushaar BS, Nirschl RP. Tendinosis of the elbow (tennis elbow). Clinical features and findings of histological, immunohistochemical, and electron microscopy studies. J Bone Joint Surg Am 1999;81:259-78.  Back to cited text no. 15
Eppley BL, Woodell JE, Higgins J. Platelet quantification and growth factor analysis from platelet-rich plasma: Implications for wound healing. Plast Reconstr Surg 2004;114:1502-8.  Back to cited text no. 16
Fredberg U, Stengaard-Pedersen K. Chronic tendinopathy tissue pathology, pain mechanisms, and etiology with a special focus on inflammation. Scand J Med Sci Sports 2008;18:3-15.  Back to cited text no. 17
Fredberg U, Bolvig L, Pfeiffer-Jensen M, Clemmensen D, Jakobsen BW, Stengaard-Pedersen K. Ultrasonography as a tool for diagnosis, guidance of local steroid injection and together with pressure algometry monitoring of the treatment of athletes with chronic jumper's knee and achilles tendinitis: A randomised, double-blind, placebo-controlled study. Scand J Rheumatol 2004;33:94-101.  Back to cited text no. 18
Hoppe S, Alini M, Benneker LM, Milz S, Boileau P, Zumstein MA. Tenocytes of chronic rotator cuff tendon tears can be stimulated by platelet-released growth factors. J Shoulder Elbow Surg 2013;22:340-9.  Back to cited text no. 19
Jo CH, Kim JE, Yoon KS, Shin S. Platelet-rich plasma stimulates cell proliferation and enhances matrix gene expression and synthesis in tenocytes from human rotator cuff tendons with degenerative tears. Am J Sports Med 2012;40:1035-45.  Back to cited text no. 20


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