Year : 2018  |  Volume : 6  |  Issue : 1  |  Page : 3-8

Antifibrinolyticin reducing postoperative blood loss in total hip replacement and its effect on coagulation profile: A prospective randomized study

1 Department of Orthopedics, GGS Medical College, Faridkot, Punjab, India
2 Department of Orthopedics, Gian Sagar Medical College, Banur, Punjab, India
3 Department of Radiodiagnosis, GGS Medical College, Faridkot, Punjab, India

Correspondence Address:
Dr. Anshul Dahuja
GGS Medical College, Faridkot, Punjab
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/joas.joas_2_18

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BACKGROUND: Studies have shown that tranexamic acid reduces blood loss and transfusion need in patients undergoing total hip arthroplasty. However, till date, no study has been large enough to determine definitively whether the drug is safe and effective in total hip arthroplasty. We examined whether intravenous tranexamic acid, when compared with placebo, is safe and effective in total hip arthroplasty. MATERIALS AND METHODS: A prospective, randomized, double blinded study was conducted in a group of 142 patients undergoing total hip arthroplasty divided equally into tranexamic acid group and control group. Our protocol included administration of one dose of 15 mg/kg of TXA (given as infusion over 15 min ) in 100 ml NS just 15 min before incision and the subsequent 8 hourly in TXA group. In control group we have given 100 ml normal saline infusion just before operation and 100 ml NS infusion 8 hourly for 2 days postoperatively. Postoperative blood parameters were recorded. RESULTS: The total postoperative drain output and transfusion requirement was found to be lower in patients who received TXA (352-412 ml) as compared to control group (804-878 ml). We have observed 3 and 4 cases of DVT in TXA and control group respectively. Coagulation profile is least affected in both the groups. CONCLUSION: We conclude that tranexamic acid significantly reduces postoperative blood loss and transfusion requirements during total hip arthroplasty.

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